2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

Related Products

PDF 0.83 MB

Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108910A
    Chymotrypsin (MS grade)
    Chymotrypsin (Chymotrypsin A) (MS grade) is a serine protease produced by the pancreas. Chymotrypsin (MS grade) cleaves protein chains at the carboxyl side of aromatic amino acids.
    Chymotrypsin (MS grade)
  • HY-165529
    Camostat
    		Inhibitor 99.42%
    Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs).
    Camostat
  • HY-14853
    Darexaban
    		Inhibitor 98.05%
    Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects.
    Darexaban
  • HY-105999
    APC 366
    		Inhibitor 99.81%
    APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma.
    APC 366
  • HY-P4462
    D-Leu-Thr-Arg-pNA
    		Substrate 98.08%
    D-Leu-Thr-Arg-pNA is a substrate for γ-Tryptase, and can be used to measure the effects of small molecule inhibitors on γ-Tryptase activity.
    D-Leu-Thr-Arg-pNA
  • HY-126361A
    ZK824190 hydrochloride
    		Inhibitor 99.24%
    ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
    ZK824190 hydrochloride
  • HY-134932
    AA74-1
    		Inhibitor ≥98.0%
    AA74-1 is a potent and selective inhibitor of APEH. AA74-1 significantly increases T cells proliferation by blocking the APEH activity.
    AA74-1
  • HY-E70194
    Endoproteinase Glu-C
    Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins.
    Endoproteinase Glu-C
  • HY-137458
    Vevorisertib
    		98.03%
    Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor against AKT1 (IC50=0.55 nM), AKT2 (IC50=0.81 nM), and AKT3 (IC50=1.31 nM). Vevorisertib, as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations.
    Vevorisertib
  • HY-P990387
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
    		99.28%
    The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) is a humanized antibody expressed in CHO cells, targeting CTSS/Cathepsin S. The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CTSS/Cathepsin S Antibody (Fsn0503h) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
  • HY-122762
    Cetraxate hydrochloride
    		Inhibitor 99.37%
    Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively.
    Cetraxate hydrochloride
  • HY-P0133A
    (Arg)9 TFA
    		Inhibitor 99.57%
    (Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg)9 TFA
  • HY-P4476
    Suc-AAPA-pNA
    		Inhibitor 98.02%
    Suc-AAPA-pNA is a substrate of chymotrypsin Aα. Suc-AAPA-pNA can be used to test chymotrypsin Aα activity.
    Suc-AAPA-pNA
  • HY-P3798
    Eglin c (41-49)
    Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with Ki values of 42 and 20 μM, respectively.
    Eglin c (41-49)
  • HY-148239
    TP-030-2
    		Inhibitor 98.32%
    TP-030-2 is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM).
    TP-030-2
  • HY-154790
    STn/sialyl-Tn
    STn/sialyl-Tn is a sialic acid associated with breast cancer and its expression is closely related to HER2-pos. STn/sialyl-Tn can be used as a marker to count cells in malignant nipple discharge (PND).
    STn/sialyl-Tn
  • HY-B0190S1
    Nafamostat formate salt-13C6
    		98.11%
    Nafamostat formate salt-13C6 is the 13C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2.
    Nafamostat formate salt-<sup>13</sup>C<sub>6</sub>
  • HY-B0190
    Nafamostat
    		Inhibitor
    Nafamostat, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat has anticancer and antivirus effect. Nafamostat induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat can be used in the development of the pathological thickening of the arterial wall.
    Nafamostat
  • HY-P0206A
    Bradykinin acetate
    		Inhibitor
    Bradykinin acetate is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin acetate can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain.
    Bradykinin acetate
  • HY-145263
    VD2173
    		Inhibitor
    VD2173 is a side chain cyclized macrocyclic peptide inhibitor of HGF-activating serine proteases. VD2173 potently inhibits matriptase and hepsin. VD2173 can be used for the research of lung cancer.
    VD2173
Cat. No. Product Name / Synonyms Application Reactivity