2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-E70203
    Recombinant aprotinin
    		Inhibitor
    Recombinant aprotinin is a serine protease inhibitor. Recombinant aprotinin can inhibit trypsin and related proteolytic enzymes.
    Recombinant aprotinin
  • HY-E70194
    Endoproteinase Glu-C
    Endoproteinase GluC (V8 protease) is a serine proteinase. Endoproteinase GluC is able to hydrolyze some serpins and all classes of mammalian immunoglobulins.
    Endoproteinase Glu-C
  • HY-156818
    TNIK-IN-7
    		Inhibitor 99.90%
    TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity.
    TNIK-IN-7
  • HY-P991312
    CM-338
    		Inhibitor
    CM-338 is a human monoclonal antibody (mAb) targeting MASP2. CM-338 can be used in IgA nephropathy research.
    CM-338
  • HY-P4476
    Suc-AAPA-pNA
    		Inhibitor 98.19%
    Suc-AAPA-pNA is a substrate of chymotrypsin Aα. Suc-AAPA-pNA can be used to test chymotrypsin Aα activity.
    Suc-AAPA-pNA
  • HY-14853
    Darexaban
    		Inhibitor 98.05%
    Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects.
    Darexaban
  • HY-105999
    APC 366
    		Inhibitor 99.81%
    APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma.
    APC 366
  • HY-P4462
    D-Leu-Thr-Arg-pNA
    		Substrate 98.08%
    D-Leu-Thr-Arg-pNA is a substrate for γ-Tryptase, and can be used to measure the effects of small molecule inhibitors on γ-Tryptase activity.
    D-Leu-Thr-Arg-pNA
  • HY-126361A
    ZK824190 hydrochloride
    		Inhibitor 99.24%
    ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.
    ZK824190 hydrochloride
  • HY-19727A
    FOY 251
    		Inhibitor 98.86%
    FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay.
    FOY 251
  • HY-P990387
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
    		99.28%
    The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) is a humanized antibody expressed in CHO cells, targeting CTSS/Cathepsin S. The Anti-CTSS/Cathepsin S Antibody (Fsn0503h) has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CTSS/Cathepsin S Antibody (Fsn0503h) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CTSS/Cathepsin S Antibody (Fsn0503h)
  • HY-122762
    Cetraxate hydrochloride
    		Inhibitor 99.37%
    Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively.
    Cetraxate hydrochloride
  • HY-P4310
    Boc-Val-Leu-Lys-AMC
    		98.93%
    Boc-Val-Leu-Lys-AMC is a sensitive, fluorogenic, and specific substrate of plasmin, as well as acrosin from the ascidian Halocynthia roretzi, porcine calpain isozymes I and II, and papain.
    Boc-Val-Leu-Lys-AMC
  • HY-153752
    TAO Kinase inhibitor 2
    		Inhibitor
    TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC50=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC50s of 50-500 nM.
    TAO Kinase inhibitor 2
  • HY-129263
    L-Isoleucyl-L-valine
    L-Isoleucyl-L-valine (Ile-Val) is a dipeptide that induces the bovine trypsinogen-trypsin transition.
    L-Isoleucyl-L-valine
  • HY-P0133A
    (Arg)9 TFA
    		Inhibitor 99.57%
    (Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg)9 TFA
  • HY-P3798
    Eglin c (41-49)
    Eglin c (41-49) is a peptide fragment related to eglin c. Eglin c (41-49) shows inhibitory effects to cathepsin G and α-chymotrypsin with Ki values of 42 and 20 μM, respectively.
    Eglin c (41-49)
  • HY-134932
    AA74-1
    		Inhibitor ≥98.0%
    AA74-1 is a potent and selective inhibitor of APEH. AA74-1 significantly increases T cells proliferation by blocking the APEH activity.
    AA74-1
  • HY-W014226
    4,4'-Dihydroxybenzophenone
    		Modulator 99.82%
    4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (KA = 7.59 x 105 L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna.
    4,4'-Dihydroxybenzophenone
  • HY-148239
    TP-030-2
    		Inhibitor 98.32%
    TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM).
    TP-030-2
Cat. No. Product Name / Synonyms Application Reactivity